The confirmation of Hamza's death has come more than a month after the US media reported that he was killed, citing the US intelligence officials.
The US State Department had identified him as a "Specially Designated Global Terrorist" in January 2017.
The sanctions list subjected him to a travel ban, assets freeze and an arms embargo.
The US move comes nearly year and half after Hamza was officially announced by al-Qaeda chief Ayman al-Zawahiri as an official member of the group.
Hamza bin Laden promised to continue the global militant group's fight against the United States.
In the website, the boy dubbed the 'Crown Prince of Terror', called for an acceleration in the destruction of America, Britain, France and Denmark, the latter singled out for the publishing by its largest selling broadsheet of caricatures of the Prophet Mohammed.Hamza Bin Ladan, 16, the youngest of the Saudi-born warlord's 18 sons, is claimed to be the author of a poem featured on an extremist website to mark the third anniversary of the July 7 London bombings.
Hamza, 29, has assumed a senior position within Al Qaeda and was aiming to avenge the death of his father, who was shot dead during a covert US military raid in Pakistan's Abbottabad seven years ago, Osama's half-brothers Ahmad and Hassan al-Attas were quoted as saying.
Here are the things we know about Osama and his terror group from the documents.
Ali Soufan, the former FBI agent who was the bureau's lead investigator of Al Qaeda after the 9/11 attacks, told CBS News the letters reveal Hamza to be a young man who adores his father and wants to carry on his murderous ideology.
Bhutto, who survived the terror attack in Karachi on October 18 that killed nearly 140 people and injured hundreds more, said the restoration of democracy is a must to save Pakistan.
A 56-year old British cleric has been sentenced to life in prison by a court in US after being convicted of 11 terror-related charges, including providing material support to Al Qaeda and conspiring to establish a terrorist training camp in the US.
The perpetrators of the 2008 Mumbai attack, who shot dead 166 people, had confessed to details that should have been enough to hang him, but Pakistan enjoyed his anti-India rhetoric and let him spread his tentacles. A revealing excerpt from Khaled Ahmed's Pakistan's Terror Conundrum.